SCI-Arc's faculty represents a wide range of contemporary approaches to Architecture and related disciplines. Among its members are renowned theorists, critics and historians and some of Los Angeles's leading architectural practitioners who have devoted their careers to investigating how broad aesthetic, social and cultural concerns can be integrated into an overall understanding of the built and natural environments.

SCI-Arc also attracts visiting faculty from around the world whose work has placed them firmly at the forefront of the discipline. Visiting instructors have included Raimund Abraham, Lise-Anne Couture, Odile Decq, Bill MacDonald, Jeffrey Kipnis, Norman Klein, Sulan Kolatan, Neil Leach, Brendan MacFarlane, Michael Maltzan, Monica Ponce de Leon, and Michele Saee.